Frontal tDCS modulates orbitofrontal reality filtering.
Neuroscience
; 265: 21-7, 2014 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-24508152
ABSTRACT
Orbitofrontal reality filtering denotes a memory control mechanism necessary to keep thought and behavior in phase with reality. Its failure induces reality confusion as evident in confabulation and disorientation. In the present study, we explored the influence of orbitofrontal transcranial direct current stimulation (tDCS) on reality filtering. Twenty healthy human subjects made a reality filtering task, while receiving cathodal, anodal, or sham stimulation over the frontal pole in three sessions separated by at least 1week. Computational models predicted that this montage can produce polarity-specific current flow across the posterior medial orbitofrontal cortex (OFC). In agreement with our hypothesis, we found that cathodal tDCS over the frontal pole specifically impaired reality filtering in comparison to anodal and sham stimulation. This study shows that reality filtering, an orbitofrontal function, can be modulated with tDCS.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
/
Reconhecimento Psicológico
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Memória
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2014
Tipo de documento:
Article