The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.

Joseph, Jason P; Mecca, Adam P; Regenhardt, Robert W; Bennion, Douglas M; Rodríguez, Vermali; Desland, Fiona; Patel, Neal A; Pioquinto, David J; Unger, Thomas; Katovich, Michael J; Steckelings, U Muscha; Sumners, Colin

Joseph, Jason P; Mecca, Adam P; Regenhardt, Robert W; Bennion, Douglas M; Rodríguez, Vermali; Desland, Fiona; Patel, Neal A; Pioquinto, David J; Unger, Thomas; Katovich, Michael J; Steckelings, U Muscha; Sumners, Colin.

Afiliação

Joseph JP; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Mecca AP; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Regenhardt RW; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Bennion DM; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Rodríguez V; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Desland F; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Patel NA; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Pioquinto DJ; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Unger T; School for Cardiovascular Diseases, Maastricht University, Netherlands.
Katovich MJ; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
Steckelings UM; Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.
Sumners C; Department of Physiology and Functional Genomics & McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Electronic address: csumners@ufl.edu.

Neuropharmacology ; 81: 134-41, 2014 Jun.

Article em En | MEDLINE | ID: mdl-24508710

Assuntos

Bloqueadores do Receptor Tipo 2 de Angiotensina II/uso terapêutico; Isquemia Encefálica/induzido quimicamente; Isquemia Encefálica/complicações; Circulação Cerebrovascular/efeitos dos fármacos; Endotelina-1/toxicidade; Acidente Vascular Cerebral; Animais; Infarto Encefálico/tratamento farmacológico; Infarto Encefálico/etiologia; Antígeno CD11b/genética; Antígeno CD11b/metabolismo; Citocinas/genética; Citocinas/metabolismo; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Proteína Glial Fibrilar Ácida/genética; Proteína Glial Fibrilar Ácida/metabolismo; Imidazóis/uso terapêutico; Masculino; Óxido Nítrico Sintase Tipo II/genética; Óxido Nítrico Sintase Tipo II/metabolismo; Peroxidase/genética; Peroxidase/metabolismo; Piridinas/uso terapêutico; Ratos; Ratos Sprague-Dawley; Acidente Vascular Cerebral/etiologia; Acidente Vascular Cerebral/fisiopatologia; Acidente Vascular Cerebral/prevenção & controle; Sulfonamidas/farmacologia; Sulfonamidas/uso terapêutico; Tiofenos/farmacologia; Tiofenos/uso terapêutico; Fatores de Tempo

Palavras-chave

Angiotensin type 2 receptor; Chemokine; Compound 21; Endothelin-1; Ischemia; Stroke

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Circulação Cerebrovascular / Endotelina-1 / Acidente Vascular Cerebral / Bloqueadores do Receptor Tipo 2 de Angiotensina II Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2014 Tipo de documento: Article

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