AB0 incompatible kidney transplantation using unspecific immunoadsorption.
Transfus Apher Sci
; 50(2): 263-6, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24517873
ABSTRACT
BACKGROUND:
A protocol for ABO-incompatible kidney transplantation with antigen specific immunoadsorption, rituximab and conventional immunosuppression has been successfully implemented in many European centers. We report an alternative method for the elimination of isoagglutinins with a number of advantages - large amount of treatable plasma, parallel removal of other rejection-inducing antibodies, long operating life, favorable cost-benefit ratio.METHOD:
We report our first successfully treated case of an ABO-incompatible living donor kidney transplantation using Immunoadsorption with Ig-TheraSorb. We performed 5 sessions preoperatively and one after transplantation. Per treatment session twice the calculated plasma volume (4400 ml in this patient) was treated.RESULTS:
Per treatment session the IgM- isoagglutinin-titers were reduced from 116 to 11 and the IgG- isoagglutinin-titers from 132 to 12. There were no side effects and the procedure was well tolerated with good renal function 500 days post transplantation.CONCLUSION:
Ig-TheraSorb-Immunoadsorption is an alternative method of elimination of harmful antibodies and it enables successful integration of ABO-incompatible transplantation into regular transplantation programs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doadores de Tecidos
/
Remoção de Componentes Sanguíneos
/
Sistema ABO de Grupos Sanguíneos
/
Transplante de Rim
/
Aglutininas
Tipo de estudo:
Guideline
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Transfus Apher Sci
Ano de publicação:
2014
Tipo de documento:
Article