Safety of an intravenous formulation of lamotrigine.
Seizure
; 23(5): 390-2, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24560492
ABSTRACT
PURPOSE:
Intravenous (IV) formulations are useful when treating patients where oral administration is not possible and to study certain pharmacokinetic parameters such as bioavailability. We developed a stable-labeled IV formulation of lamotrigine (LTG) for studying pharmacokinetics in epilepsy patients.METHODS:
Stable-labeled IV LTG was given to 20 persons with epilepsy (6 men; 14 women) with a mean age of 34.8 years (SD 11.7). A 50mg dose of LTG (stable labeled) was given intravenously and replaced 50mg of the regular morning oral dose of LTG (unlabeled, commercially available formulation).RESULTS:
No significant changes in blood pressure, heart rate, or adverse events including rash were attributed to administration of a 50-mg dose of the intravenous LTG formulation.CONCLUSION:
Our results show that LTG base that is complexed with 2-hydroxypropyl-ß-cyclodextrin and stable-labeled can be given safely as a tracer replacement dose.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazinas
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Epilepsia
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Anticonvulsivantes
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Seizure
Ano de publicação:
2014
Tipo de documento:
Article