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Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe.
Coda, Sergio; Thompson, Alex J; Kennedy, Gordon T; Roche, Kim L; Ayaru, Lakshmana; Bansi, Devinder S; Stamp, Gordon W; Thillainayagam, Andrew V; French, Paul M W; Dunsby, Chris.
Afiliação
  • Coda S; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK ; Endoscopy Unit, Department of Gastroenterology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London, W6 8RF, UK ; These authors contributed equally to thi
  • Thompson AJ; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK ; These authors contributed equally to this work.
  • Kennedy GT; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK.
  • Roche KL; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK ; Endoscopy Unit, Department of Gastroenterology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London, W6 8RF, UK.
  • Ayaru L; Endoscopy Unit, Department of Gastroenterology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London, W6 8RF, UK.
  • Bansi DS; Endoscopy Unit, Department of Gastroenterology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London, W6 8RF, UK.
  • Stamp GW; Department of Histopathology, Imperial College London, Du Cane Road, London, W12 0NN, UK ; Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
  • Thillainayagam AV; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK ; Endoscopy Unit, Department of Gastroenterology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London, W6 8RF, UK ; These authors contributed equally to thi
  • French PM; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK ; These authors contributed equally to this work.
  • Dunsby C; Photonics Group, Department of Physics, Imperial College London, Prince Consort Road, London, SW7 2AZ, UK ; Department of Histopathology, Imperial College London, Du Cane Road, London, W12 0NN, UK ; These authors contributed equally to this work.
Biomed Opt Express ; 5(2): 515-38, 2014 Feb 01.
Article em En | MEDLINE | ID: mdl-24575345
ABSTRACT
We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm. A paired analysis of normal and neoplastic (adenomatous polyp) tissue specimens obtained from the same patient yielded a significant difference in the mean spectrally averaged autofluorescence lifetime -570 ± 740 ps (p = 0.021, n = 12). We also investigated the fluorescence signature of non-neoplastic polyps (n = 6) and inflammatory bowel disease (n = 4) compared to normal tissue in a small number of specimens.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2014 Tipo de documento: Article