The contractile response of vascular smooth muscle to thrombin and its inhibition by thrombin inhibitors.
Folia Haematol Int Mag Klin Morphol Blutforsch
; 115(1-2): 94-100, 1988.
Article
em En
| MEDLINE
| ID: mdl-2459039
ABSTRACT
Thrombin (0.1-30 NIH-U/ml) caused a contractile response of rabbit aortic rings. The vasocontraction was independent upon intact endothelium, however in deendothelialized vessels the contractile effect was more pronounced. The thrombin-induced vasocontraction was diminished in calcium-free medium; the same effect was attained by the calcium channel blocker verapamil at high concentrations. In human femoral and saphenous vein strips thrombin produced a contractile effect, too, which was very low and inconsistent in femoral arterial strips. To inhibit the contractile response of vascular smooth muscle to thrombin, higher concentrations of both the specific tight-binding inhibitors hirudin and beta Nas-Gly-(pAM)Phe-Pip were required than for the inhibition of fibrinogen clotting.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombina
/
Contração Muscular
/
Músculo Liso Vascular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Folia Haematol Int Mag Klin Morphol Blutforsch
Ano de publicação:
1988
Tipo de documento:
Article