Bisphosphonate-related atypical femoral fracture with bone metastasis of breast cancer: case report and review.
Anticancer Res
; 34(3): 1245-9, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24596367
ABSTRACT
BACKGROUND:
Intravenous bisphosphonates (BPs) have been used to reduce the frequency of skeletal-related events due to bone metastases of several kinds of cancers. Although many studies on BP-related atypical fractures (BRAFs) due to the use of BP for osteoporosis treatment have been reported, few reports on BRAFs arising as a complication of long-term BP use for bone metastasis of cancer are available. CASE REPORT A 62-year-old woman with a history of breast cancer presented with right thigh pain after she had a fall. Radiographs indicated a transverse fracture in the shaft of the right femur. She had been on zoledronate treatment for six years. Based on radiographic and histopathological findings, we concluded that the fracture was not a pathological fracture associated with metastasis but was a complication of long-term BP treatment.CONCLUSION:
Clinical oncologists should consider the possibility of BRAFs in patients on long-term zoledronate treatment for bone metastases.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ósseas
/
Neoplasias da Mama
/
Difosfonatos
/
Conservadores da Densidade Óssea
/
Fraturas do Fêmur
/
Imidazóis
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2014
Tipo de documento:
Article