Assessment of atrial electromechanical delay in patients with polycystic ovary syndrome in both lean and obese subjects.
J Obstet Gynaecol Res
; 40(4): 1059-66, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24612019
ABSTRACT
AIM:
Even though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group.METHODS:
The study population comprised 50 women 18-40 years of age who had been diagnosed with PCOS. The patients were divided into two groups lean women (L-PCOS) with a body mass index (BMI) under 25 kg/m² and obese women (O-PCOS) with a BMI greater than 30 kg/m². Twenty-five age-matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P-wave duration was calculated and was defined as P-wave dispersion (Pd). Inter- and intra-atrial electromechanical delays (inter-AED, intra-AED, respectively) were measured with tissue Doppler imaging.RESULTS:
Inter- and intra-AED parameters were higher in the L-PCOS group when compared with control subjects (anova, P=0.004 and P=0.013, respectively), and were also significantly higher in the O-PCOS group compared with other groups (anova, P<0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) (ß=0.603, P<0.001) and BMI (ß=0.379, P<0.001) were the independent predictors of inter-AED, HOMA-IR (ß=0.835, P<0.001) was an independent predictor of intra-AED, and BMI (ß=0.457, P=0.006) and the left atrial diameter (ß=0.350, P<0.034) were independent predictors of Pd.CONCLUSION:
Consequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Fibrilação Atrial
/
Obesidade
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Obstet Gynaecol Res
Ano de publicação:
2014
Tipo de documento:
Article