Antibacterial properties of the CFTR potentiator ivacaftor.
J Cyst Fibros
; 13(5): 515-9, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24618508
ABSTRACT
BACKGROUND:
Ivacaftor increases CFTR channel activity and improves pulmonary function for individuals bearing a G551D mutation. Because ivacaftor structurally resembles quinolone antibiotics, we tested the hypothesis that ivacaftor possesses antibacterial properties.METHODS:
Bioluminescence, colony forming unit, and minimal inhibitory concentration assays were used to assess viability of Staphylococcus aureus, Pseudomonas aeruginosa and multiple clinical microbial isolates.RESULTS:
Ivacaftor induced a dose-dependent reduction in bioluminescence of S. aureus and decreased the number of colony forming units. We observed a similar but less robust effect in P. aeruginosa following outer membrane permeabilization. Ivacaftor inhibited the growth of respiratory isolates of S. aureus and Streptococcus pneumoniae and exhibited positive interactions with antibiotics against lab and respiratory strains of S. aureus and S. pneumoniae.CONCLUSION:
These data indicate that ivacaftor exhibits antibacterial properties and raise the intriguing possibility that ivacaftor might have an antibiotic effect in people with CF.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Quinolonas
/
Regulador de Condutância Transmembrana em Fibrose Cística
/
Aminofenóis
/
Antibacterianos
Idioma:
En
Revista:
J Cyst Fibros
Ano de publicação:
2014
Tipo de documento:
Article