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2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
Wu, Sherry Y; Yang, Xianbin; Gharpure, Kshipra M; Hatakeyama, Hiroto; Egli, Martin; McGuire, Michael H; Nagaraja, Archana S; Miyake, Takahito M; Rupaimoole, Rajesha; Pecot, Chad V; Taylor, Morgan; Pradeep, Sunila; Sierant, Malgorzata; Rodriguez-Aguayo, Cristian; Choi, Hyun J; Previs, Rebecca A; Armaiz-Pena, Guillermo N; Huang, Li; Martinez, Carlos; Hassell, Tom; Ivan, Cristina; Sehgal, Vasudha; Singhania, Richa; Han, Hee-Dong; Su, Chang; Kim, Ji Hoon; Dalton, Heather J; Kovvali, Chandra; Keyomarsi, Khandan; McMillan, Nigel A J; Overwijk, Willem W; Liu, Jinsong; Lee, Ju-Seog; Baggerly, Keith A; Lopez-Berestein, Gabriel; Ram, Prahlad T; Nawrot, Barbara; Sood, Anil K.
Afiliação
  • Wu SY; 1] Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA [2].
  • Yang X; 1] AM Biotechnologies LLC, 12521 Gulf Freeway, Houston, Texas 77034, USA [2].
  • Gharpure KM; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Hatakeyama H; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Egli M; Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA.
  • McGuire MH; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Nagaraja AS; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Miyake TM; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Rupaimoole R; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Pecot CV; Division of Cancer Medicine, MDACC, Houston, Texas 77054, USA.
  • Taylor M; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Pradeep S; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Sierant M; Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Lodz, Poland.
  • Rodriguez-Aguayo C; 1] Department of Experimental Therapeutics, MDACC, Houston, Texas 77054, USA [2] Center for RNA Interference and Non-Coding RNA, MDACC, Houston, Texas 77054, USA.
  • Choi HJ; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Previs RA; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Armaiz-Pena GN; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Huang L; Department of Cancer Biology, MDACC, Houston, Texas 77054, USA.
  • Martinez C; Sigma Life Science, 9186 Six Pines, The Woodlands, Texas 77380, USA.
  • Hassell T; Sigma Life Science, 9186 Six Pines, The Woodlands, Texas 77380, USA.
  • Ivan C; 1] Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA [2] Center for RNA Interference and Non-Coding RNA, MDACC, Houston, Texas 77054, USA.
  • Sehgal V; Department of Systems Biology, MDACC, Houston, Texas 77054, USA.
  • Singhania R; 1] University of Queensland Diamantina Institute, Woolloongabba, Queensland 4102, Australia [2] Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham NG7 2RD, UK.
  • Han HD; 1] Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA [2] Center for RNA Interference and Non-Coding RNA, MDACC, Houston, Texas 77054, USA [3] Department of Immunology Laboratory, School of Medicine, Konkuk University, Chungju 380
  • Su C; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Kim JH; 1] Department of Systems Biology, MDACC, Houston, Texas 77054, USA [2] Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul 136-701, Korea.
  • Dalton HJ; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Kovvali C; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA.
  • Keyomarsi K; Department of Experimental Radiation Oncology, MDACC, Houston, Texas 77054, USA.
  • McMillan NA; 1] University of Queensland Diamantina Institute, Woolloongabba, Queensland 4102, Australia [2] Griffith Health Institute and School of Medical Sciences, Griffith University, Southport, Queensland 4222, Australia.
  • Overwijk WW; Department of Melanoma Medical Oncology, MDACC, Houston, Texas 77054, USA.
  • Liu J; Department of Pathology, MDACC, Houston, Texas 77054, USA.
  • Lee JS; Department of Systems Biology, MDACC, Houston, Texas 77054, USA.
  • Baggerly KA; Department of Bioinformatics, MDACC, Houston, Texas 77054, USA.
  • Lopez-Berestein G; 1] Department of Experimental Therapeutics, MDACC, Houston, Texas 77054, USA [2] Center for RNA Interference and Non-Coding RNA, MDACC, Houston, Texas 77054, USA.
  • Ram PT; Department of Systems Biology, MDACC, Houston, Texas 77054, USA.
  • Nawrot B; Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Lodz, Poland.
  • Sood AK; 1] Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, Texas 77054, USA [2] Center for RNA Interference and Non-Coding RNA, MDACC, Houston, Texas 77054, USA [3] Department of Cancer Biology, MDACC, Houston, Texas 77054, USA.
Nat Commun ; 5: 3459, 2014 Mar 12.
Article em En | MEDLINE | ID: mdl-24619206
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Complexo de Inativação Induzido por RNA / RNA Interferente Pequeno Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Complexo de Inativação Induzido por RNA / RNA Interferente Pequeno Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Ano de publicação: 2014 Tipo de documento: Article