Data mining from a 27-years rotavirus surveillance in Palermo, Italy.
Infect Genet Evol
; 28: 377-84, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24632456
ABSTRACT
Uninterrupted surveillance conducted in Palermo, Sicily, for 27 years (1985-2012) detected rotavirus infection in 32.7% of 6522 children <5 years of age, hospitalised at the "G. Di Cristina" Children's Hospital of Palermo. Increased rotavirus activity usually occurred from the beginning of winter to mid-spring. G1P[8] rotaviruses were the prevalent strains in most of the years and were only occasionally overcome by G9P[8], G4P[8] or G2P[4]. The circulation of non-G1P[8] strains was discontinuous and fluctuating. Phylogenetic analyses revealed an heterogeneous population of viruses within each genotype, with different lineages and sublineages emerging over the time. Amino acid substitutions in both VP7 and VP8(∗) antigenic epitopes were generally associated with different lineages/sublineages, emerging sequentially and replacing partially or completely the former strains. The present study summarises one of the longest surveillance activities conducted in the European continent, offering a useful temporal observatory of rotavirus epidemiology and strains variation and evolution in a settled population.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
/
Rotavirus
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Child, preschool
/
Humans
/
Infant
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
Infect Genet Evol
Ano de publicação:
2014
Tipo de documento:
Article