Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates.
Bioorg Med Chem Lett
; 24(7): 1856-61, 2014 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-24641976
ABSTRACT
Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Sulfadiazina
/
Quinolonas
/
Aminoácidos
/
Metronidazol
/
Antibacterianos
Tipo de estudo:
Guideline
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2014
Tipo de documento:
Article