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Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates.
Ibrahim, Mohamed A; Panda, Siva S; Birs, Antoinette S; Serrano, Juan C; Gonzalez, Claudio F; Alamry, Khalid A; Katritzky, Alan R.
Afiliação
  • Ibrahim MA; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States; Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, PO Box 77, Egypt.
  • Panda SS; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States.
  • Birs AS; Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611-7200, United States.
  • Serrano JC; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States.
  • Gonzalez CF; Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611-7200, United States.
  • Alamry KA; Chemistry Department, King Abdulaziz University, Jeddah 21589 Saudi Arabia.
  • Katritzky AR; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States; Chemistry Department, King Abdulaziz University, Jeddah 21589 Saudi Arabia. Electronic address: katritzky@chem.ufl.edu.
Bioorg Med Chem Lett ; 24(7): 1856-61, 2014 Apr 01.
Article em En | MEDLINE | ID: mdl-24641976
ABSTRACT
Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5α), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Sulfadiazina / Quinolonas / Aminoácidos / Metronidazol / Antibacterianos Tipo de estudo: Guideline Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Sulfadiazina / Quinolonas / Aminoácidos / Metronidazol / Antibacterianos Tipo de estudo: Guideline Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article