Recombinant viruses initiated the early HIV-1 epidemic in Burkina Faso.
PLoS One
; 9(3): e92423, 2014.
Article
em En
| MEDLINE
| ID: mdl-24647246
ABSTRACT
We analyzed genetic diversity and phylogenetic relationships among 124 HIV-1 and 19 HIV-2 strains in sera collected in 1986 from patients of the state hospital in Ouagadougou, Burkina Faso. Phylogenetic analysis of the HIV-1 env gp41 region of 65 sequences characterized 37 (56.9%) as CRF06_cpx strains, 25 (38.5%) as CRF02_AG, 2 (3.1%) as CRF09_cpx, and 1 (1.5%) as subtype A. Similarly, phylogenetic analysis of the protease (PR) gene region of 73 sequences identified 52 (71.2%) as CRF06_cpx, 15 (20.5%) as CRF02_AG, 5 (6.8%) as subtype A, and 1 (1.4%) was a unique strain that clustered along the B/D lineage but basal to the node connecting the two lineages. HIV-2 PR or integrase (INT) groups A (nâ=â17 [89.5%]) and B (nâ=â2 [10.5%]) were found in both monotypic (nâ=â11) and heterotypic HIV-1/HIV-2 (nâ=â8) infections, with few HIV-2 group B infections. Based on limited available sampling, evidence suggests two recombinant viruses, CRF06_cpx and CRF02_AG, appear to have driven the beginning of the mid-1980s HIV-1 epidemic in Burkina Faso.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
HIV-1
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
PLoS One
Ano de publicação:
2014
Tipo de documento:
Article