Retrospective analysis of 119 small bowel adenocarcinoma in Chinese patients.
Cancer Invest
; 32(5): 178-83, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24654694
ABSTRACT
BACKGROUND:
Small bowel adenocarcinoma (SBA) is a rare occurrence and few studies have addressed it adequately, especially in China.METHODS:
Clinicopathological features, survival and prognostic analysis were retrospectively done in SBA patients admitted between 2001 and 2011 in the People's Liberation Army General Hospital.RESULTS:
The study included 68 men and 51 women with a median age of 56.5 year. Tumors mainly occurred in duodenum (93.3%). Abdominal pain was the most frequent symptom (36.8%). Patients (30.3%) who received postoperative adjuvant chemotherapy had an increased, but not significant, median overall survival (MOS) rate compared to those who did not receive chemotherapy (37 vs 35 months, p = .324). One year disease free survival rate was higher in patients receiving postoperative chemotherapy (83.3% vs 71.1%). Patients survived longer in the curative surgery group (median survival time of 49.0 months) than those in the palliative group (7.0 months) (p < .001). Node-negative patients survived longer than node-positive patients (median OS 49.0 vs 21.0 months, p = .004). Depth (95% CI 1.013-1.517, p = .037), node involvement (95% CI 1.234-3.890, p = .007), palliative surgery (95% CI, 2.998-10.555, p = .0005), and the site of tumor (95% CI 0.052-0.970, p = .045) were independent predictors of OS in a multivariate analysis.CONCLUSIONS:
SBA is rare and there is lack of obvious clinical manifestations. Depth, node involvement, palliative surgery, and the site of tumor are associated with a poor prognosis. Our analysis highlights the need for further studies to find out the exact role of postoperative adjuvant chemotherapy in these patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
/
Quimioterapia Adjuvante
/
Neoplasias Duodenais
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2014
Tipo de documento:
Article