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Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.
Hu, C-M; Zhu, J; Guo, X E; Chen, W; Qiu, X-L; Ngo, B; Chien, R; Wang, Y V; Tsai, C Y; Wu, G; Kim, Y; Lopez, R; Chamberlin, A R; Lee, E Y-H P; Lee, W-H.
Afiliação
  • Hu CM; 1] Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA [2] Genomic Research Center, Academia Sinica, Taipei, Taiwan.
  • Zhu J; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Guo XE; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Chen W; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Qiu XL; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Ngo B; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Chien R; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Wang YV; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Tsai CY; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Wu G; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Kim Y; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Lopez R; Department of Chemistry, University of California, Irvine, CA, USA.
  • Chamberlin AR; Department of Chemistry, University of California, Irvine, CA, USA.
  • Lee EY; Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.
  • Lee WH; 1] Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA [2] Genomic Research Center, Academia Sinica, Taipei, Taiwan [3] Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
Oncogene ; 34(10): 1220-30, 2015 Mar 05.
Article em En | MEDLINE | ID: mdl-24662830
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteínas Serina-Treonina Quinases / Neoplasias Tipo de estudo: Prognostic_studies Idioma: En Revista: Oncogene Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteínas Serina-Treonina Quinases / Neoplasias Tipo de estudo: Prognostic_studies Idioma: En Revista: Oncogene Ano de publicação: 2015 Tipo de documento: Article