ß-Cyclodextrin assisted solubilization of Cu and Cr complexes of flavonoids in aqueous medium: a DNA-interaction study.

Cu and Cr complexes of three flavonoids (morin, quercetin and 6-hydroxyflavone) were synthesized and included in beta-cyclodextrin (ßCD) with the objective of improving their pharmacokinetic profiles. Then binding with ds.DNA was studied to monitor their interactive tendencies at physiological conditions. The binding constants and other thermodynamic data from UV-vis spectroscopy and cyclic voltammetry revealed Cr-flavonoid-ßCD to interact with ds.DNA at pH-7.4 through electrostatic mode of binding while Cu-flavonoid-ßCD can intercalate into DNA. The strong binding propensity of Cu-flavonoid-ßCD with ds.DNA encourages their application as anticancerous agent.