Maternal choline supplementation: a nutritional approach for improving offspring health?
Trends Endocrinol Metab
; 25(5): 263-73, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24680198
ABSTRACT
The modulatory role of choline on the fetal epigenome and the impact of in utero choline supply on fetal programming and health are of great interest. Studies in animals and/or humans suggest that maternal choline supplementation during pregnancy benefits important physiologic systems such as offspring cognitive function, response to stress, and cerebral inhibition. Because alterations in offspring phenotype frequently coincide with epigenetic modifications and changes in gene expression, maternal choline supplementation may be a nutritional strategy to improve lifelong health of the child. Future studies are warranted to elucidate further the effect of choline on the fetal epigenome and to determine the level of maternal choline intake required for optimal offspring physiologic function.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colina
/
Suplementos Nutricionais
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Fenômenos Fisiológicos da Nutrição Materna
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Desenvolvimento Fetal
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Trends Endocrinol Metab
Ano de publicação:
2014
Tipo de documento:
Article