2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

Claes, Pieter; Cappoen, Davie; Uythethofken, Cynthia; Jacobs, Jan; Mertens, Birgit; Mathys, Vanessa; Verschaeve, Luc; Huygen, Kris; De Kimpe, Norbert

Claes, Pieter; Cappoen, Davie; Uythethofken, Cynthia; Jacobs, Jan; Mertens, Birgit; Mathys, Vanessa; Verschaeve, Luc; Huygen, Kris; De Kimpe, Norbert.

Afiliação

Claes P; Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Cappoen D; Scientific Service Immunology, O.D. Communicable & Infectious Diseases, Scientific Institute of Public Health (Site Ukkel), Engelandstraat 642, B-1180 Ukkel, Belgium.
Uythethofken C; Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Jacobs J; Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Mertens B; Program Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health (Site Elsene), J. Wytsmanstraat 14, B-1050 Brussels, Belgium.
Mathys V; Program Tuberculosis and Mycobacteria, O.D. Communicable & Infectious Diseases, Scientific Institute of Public Health (Site Ukkel), Engelandstraat 642, B-1180 Ukkel, Belgium.
Verschaeve L; Program Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health (Site Elsene), J. Wytsmanstraat 14, B-1050 Brussels, Belgium; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
Huygen K; Scientific Service Immunology, O.D. Communicable & Infectious Diseases, Scientific Institute of Public Health (Site Ukkel), Engelandstraat 642, B-1180 Ukkel, Belgium. Electronic address: kris.huygen@wiv-isp.be.
De Kimpe N; Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. Electronic address: norbert.dekimpe@UGent.be.

Eur J Med Chem ; 77: 409-21, 2014 Apr 22.

Article em En | MEDLINE | ID: mdl-24681334

Assuntos

Antituberculosos/farmacologia; Isoquinolinas/farmacologia; Mycobacterium tuberculosis/efeitos dos fármacos; Pirimidinonas/farmacologia; Quinonas/farmacologia; Tuberculose Resistente a Múltiplos Medicamentos/tratamento farmacológico; Animais; Antituberculosos/síntese química; Antituberculosos/química; Linhagem Celular; Relação Dose-Resposta a Droga; Isoquinolinas/síntese química; Isoquinolinas/química; Macrófagos/efeitos dos fármacos; Camundongos; Testes de Sensibilidade Microbiana; Estrutura Molecular; Mycobacterium tuberculosis/crescimento & desenvolvimento; Pirimidinonas/síntese química; Pirimidinonas/química; Quinonas/síntese química; Quinonas/química; Relação Estrutura-Atividade

Palavras-chave

Acute toxicity; Benzo[g]pyrimido[4,5-c]isoquinolinetetraones; Genotoxicity; MDR M.tb; Mycobacterium tuberculosis; Tuberculosis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Quinonas / Tuberculose Resistente a Múltiplos Medicamentos / Isoquinolinas / Mycobacterium tuberculosis / Antituberculosos Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google