Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.
Adv Healthc Mater
; 3(10): 1562-7, 1525, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24687997
ABSTRACT
Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Proteínas
/
Nanopartículas
Limite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
Adv Healthc Mater
Ano de publicação:
2014
Tipo de documento:
Article