Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.
Mol Cell Biol
; 9(2): 847-50, 1989 Feb.
Article
em En
| MEDLINE
| ID: mdl-2469006
ABSTRACT
Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Antígenos de Histocompatibilidade Classe I
Limite:
Humans
Idioma:
En
Revista:
Mol Cell Biol
Ano de publicação:
1989
Tipo de documento:
Article