Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system.
Elife
; 3: e02277, 2014 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-24692449
ABSTRACT
Bacteria have to avoid recognition by the host immune system in order to establish a successful infection. Peptidoglycan, the principal constituent of virtually all bacterial surfaces, is a specific molecular signature recognized by dedicated host receptors, present in animals and plants, which trigger an immune response. Here we report that autolysins from Gram-positive pathogenic bacteria, enzymes capable of hydrolyzing peptidoglycan, have a major role in concealing this inflammatory molecule from Drosophila peptidoglycan recognition proteins (PGRPs). We show that autolysins trim the outermost peptidoglycan fragments and that in their absence bacterial virulence is impaired, as PGRPs can directly recognize leftover peptidoglycan extending beyond the external layers of bacterial proteins and polysaccharides. The activity of autolysins is not restricted to the producer cells but can also alter the surface of neighboring bacteria, facilitating the survival of the entire population in the infected host. DOI http//dx.doi.org/10.7554/eLife.02277.001.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptidoglicano
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Drosophila
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Bactérias Gram-Positivas
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Imunidade Inata
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N-Acetil-Muramil-L-Alanina Amidase
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Elife
Ano de publicação:
2014
Tipo de documento:
Article