A comprehensive review on controls in molecular imaging: lessons from MMP-2 imaging.
Contrast Media Mol Imaging
; 9(3): 187-210, 2014.
Article
em En
| MEDLINE
| ID: mdl-24700747
ABSTRACT
Metalloproteinases (MMPs), including MMP-2, play critical roles in tissue remodeling and are involved in a large array of pathologies, including cancer, arthritis and atherosclerosis. Their prognostic value warranted a large investment or resources in the development of noninvasive detection methods, based on probes for many current clinical and pre-clinical imaging modalities. However, the potential of imaging techniques is only matched by the complexity of the data they generate. This complexity must be properly assessed and accounted for in the early steps of probe design and testing in order to accurately determine the efficacy and efficiency of an imaging strategy. This review proposes basic rules for the evaluation of novel probes by addressing the specific case of MMP targeted probes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
/
Metaloproteinase 2 da Matriz
/
Imagem Molecular
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Contrast Media Mol Imaging
Ano de publicação:
2014
Tipo de documento:
Article