Epidermal growth factor receptor (EGFR) mutations as biomarker for head and neck squamous cell carcinomas (HNSCC).
Biomarkers
; 19(3): 198-206, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24712396
ABSTRACT
CONTEXT Mutations in tyrosine kinase domain (TK) of epidermal growth factor receptor (EGFR) lead to signalling interruptions in several cancers. OBJECTIVE:
To understand EGFR mutations in head and neck squamous cell carcinomas (HNSCC), and their role as biomarkers.METHODS:
Screened 129 HNSCC patients and 150 controls for mutations in the TK domain using polymerase chain reaction (PCR), single strand confirmatory polymorphism (SSCP) and sequencing.RESULTS:
81.39% of HNSCC had four mutations G2155C, G2176A, C2188G and G2471A among these two mutations were also reported in other cancers where as two novel mutations are being reported for the first time in HNSCC. Mutational frequency was significantly associated with an advanced stage of HNSCC, habits of tobacco/alcohol and ages above 49 years.CONCLUSION:
EGFR single nucleotide polymorphisms could be useful biomarkers of HNSCC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Neoplasias de Cabeça e Pescoço
/
Mutação
Limite:
Humans
Idioma:
En
Revista:
Biomarkers
Ano de publicação:
2014
Tipo de documento:
Article