Mixed bioengineering-chemical synthesis approach for the efficient preparation of &#916;7-dafachronic acid.

Kinzurik, Matias I; Hristov, Lachezar V; Matsuda, Seiichi P T; Ball, Zachary T

Mixed bioengineering-chemical synthesis approach for the efficient preparation of Δ7-dafachronic acid.

Kinzurik, Matias I; Hristov, Lachezar V; Matsuda, Seiichi P T; Ball, Zachary T.

Afiliação

Kinzurik MI; Department of Chemistry and Department of Biochemistry and Cell Biology, Rice University , Houston, Texas 77005, United States.

Org Lett ; 16(8): 2188-91, 2014 Apr 18.

Article em En | MEDLINE | ID: mdl-24716785

RESUMO

Combining bioengineering with chemical synthesis has enabled an efficient method for producing Δ7-dafachronic acid, a steroidal hormone associated with nematode germline longevity. Saccharomyces cerevisiae was engineered to produce 7,24-cholestadienol, a convenient starting material for a four-step synthesis of Δ7-dafachronic acid.

Assuntos

Colestenos/síntese química; Saccharomyces cerevisiae/genética; Animais; Bioengenharia; Colestenos/química; Genes de Helmintos/fisiologia; Células Germinativas/metabolismo; Longevidade/fisiologia; Estrutura Molecular; Nematoides/fisiologia; Esteroides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Colestenos Limite: Animals Idioma: En Revista: Org Lett Ano de publicação: 2014 Tipo de documento: Article

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