Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.

Kennedy, Gregory D; Nukaya, Manabu; Moran, Susan M; Glover, Edward; Weinberg, Samuel; Balbo, Silvia; Hecht, Stephen S; Pitot, Henry C; Drinkwater, Norman R; Bradfield, Christopher A

Kennedy, Gregory D; Nukaya, Manabu; Moran, Susan M; Glover, Edward; Weinberg, Samuel; Balbo, Silvia; Hecht, Stephen S; Pitot, Henry C; Drinkwater, Norman R; Bradfield, Christopher A.

Afiliação

Kennedy GD; Department of Surgery, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin 53792.
Nukaya M; Department of Surgery, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin 53792.
Moran SM; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin 53706.
Glover E; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin 53706.
Weinberg S; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin 53706.
Balbo S; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455.
Hecht SS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455.
Pitot HC; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin 53706.
Drinkwater NR; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin 53706.
Bradfield CA; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin 53706 bradfield@oncology.wisc.edu.

Toxicol Sci ; 140(1): 135-43, 2014 Jul.

Article em En | MEDLINE | ID: mdl-24718703

Assuntos

Cocarcinogênese; Dioxinas/toxicidade; Neoplasias Hepáticas Experimentais/induzido quimicamente; Receptores de Hidrocarboneto Arílico/metabolismo; Receptores de Interleucina-1/metabolismo; Receptores do Fator de Necrose Tumoral/metabolismo; Animais; Caprilatos/toxicidade; Dietilnitrosamina/toxicidade; Neoplasias Hepáticas Experimentais/imunologia; Neoplasias Hepáticas Experimentais/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Receptores de Hidrocarboneto Arílico/genética; Receptores de Interleucina-1/genética; Receptores do Fator de Necrose Tumoral/genética; Triglicerídeos/toxicidade

Palavras-chave

IL-1-like cytokine; aryl hydrocarbon receptor (AHR); dioxin; liver; tumor promotion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Interleucina-1 / Cocarcinogênese / Receptores do Fator de Necrose Tumoral / Receptores de Hidrocarboneto Arílico / Dioxinas / Neoplasias Hepáticas Experimentais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Sci Ano de publicação: 2014 Tipo de documento: Article

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