EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 118(4): e115-8, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24721473
ABSTRACT
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação a Calmodulina
/
Neoplasias Mandibulares
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Tumores Odontogênicos
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Proteínas de Ligação a RNA
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Adenocarcinoma de Células Claras
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol
Ano de publicação:
2014
Tipo de documento:
Article