Prenatal exposure to antidepressants and language competence at age three: results from a large population-based pregnancy cohort in Norway.
BJOG
; 121(13): 1621-31, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24726047
ABSTRACT
OBJECTIVE:
To examine the association between maternal use of selective serotonin reuptake inhibitors (SSRI) in pregnancy and language competence in their children at age three taking into account maternal symptoms of anxiety and depression.DESIGN:
Population-based prospective pregnancy cohort study.SETTING:
The Norwegian Mother and Child Cohort Study; recruited pregnant women from 1999 through 2008. POPULATION 45,266 women with 51,748 singleton pregnancies.METHODS:
The association between short- or long-term use of SSRI during pregnancy and language competence in the child was investigated using multinomial logistic regression with three outcome categories long, complicated sentences, fairly complete sentences and language delay. MAIN OUTCOMEMEASURES:
Children's language competence at age three measured by maternal report on a validated language grammar scale.RESULTS:
Women reported use of SSRI in 386 (0.7%) pregnancies. Of these, 161 (42%) reported long-term use. Compared with children whose mothers took no SSRI, using the best language category as the reference, adjusted relative risk ratios (RRR) of having fairly complete sentences were 1.21 (95% CI 0.85-1.72) and 2.28 (1.54-3.38) for short- and long-term SSRI use, respectively. The adjusted RRRs of language delay were 0.86 (0.42-1.76) and 2.30 (1.21-4.37). Symptoms of anxiety and depression in pregnancy were independently related to language delay, adjusted RRR 1.25 (1.03-1.50) and 1.83 (1.40-2.40) for short- and long-term symptoms, respectively.CONCLUSIONS:
Prolonged use of SSRI during pregnancy was associated with lower language competence in children by age three independently of depression. Having symptoms of depression throughout pregnancy had an independent effect.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Efeitos Tardios da Exposição Pré-Natal
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Inibidores Seletivos de Recaptação de Serotonina
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Transtorno Depressivo
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Desenvolvimento da Linguagem
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Transtornos do Desenvolvimento da Linguagem
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Antidepressivos
Tipo de estudo:
Etiology_studies
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Incidence_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Child, preschool
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Female
/
Humans
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
BJOG
Ano de publicação:
2014
Tipo de documento:
Article