[Pilot study of levosimendan : Effect on liver blood flow and liver function in acute decompensated heart failure]. / Pilotstudie zu Levosimendan : Effekt auf Leberdurchblutung und -funktion bei akut dekompensierter Herzinsuffizienz.
Med Klin Intensivmed Notfmed
; 109(4): 267-70, 2014 May.
Article
em De
| MEDLINE
| ID: mdl-24743943
ABSTRACT
BACKGROUND:
In a pilot study, 9 patients (39-48 years) with acute decompensated heart failure and a cardiac index (CI) of 1.9 ± 0.3 l/min/m(2) were included after exclusion of an underlying hepatic disease. MATERIALS ANDMETHODS:
The effect of levosimendan on liver blood flow and liver function was measured with the LiMON(®) system using the indocyane green plasma disappearance rate (ICG PDR).RESULTS:
Levosimendan (Simdax(®)) infusion resulted in a significant increase of the CI, thus, achieving normal ranges of 2.9 ± 0.9 l/min/m(2) after 4 h and 3.3 ± 1 l/min/m(2) (p = 0.003) after 24 h. ICG PDR increased from 8.2 ± 0.8 % to 10.2 + 1.8 % after 4 h and to 11.9 ± 2.9 % after 24 h (p = 0.04).DISCUSSION:
The reason for the early increase in systemic blood flow with no concomitant change in ICG PDR is not clear. A primary increase in liver blood flow with sustained low liver function might be one explanation; a low flow-mediated increased release of cytokines from liver cells with consequent deterioration of liver function is another possible explanation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
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Cardiotônicos
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Falência Hepática
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Insuficiência Cardíaca
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Hidrazonas
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Fígado
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Testes de Função Hepática
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
De
Revista:
Med Klin Intensivmed Notfmed
Ano de publicação:
2014
Tipo de documento:
Article