Coexpression of keratin and vimentin in salivary pleomorphic adenomas.
J Oral Pathol Med
; 18(3): 133-9, 1989 Mar.
Article
em En
| MEDLINE
| ID: mdl-2474644
ABSTRACT
The coexpression of keratin and vimentin is described in 45 pleomorphic adenomas using an immunoperoxidase MAb method. Histopathologically, the outer layer of tubuloductal structures and peripheral tumor cells in solid masses, including modified or neoplastic myoepithelial cells, showed positive staining with monoclonal keratin antibody K8.12 and vimentin. This staining was found in the ratio of 10/26 (38.5%) in tubuloductal structures, 2/7 (28.6%) in peripheral tumor cells and 8/12 (66.7%) in modified myoepithelial cells. Concomitant staining of other keratin antibodies (PKK1, KL1) and vimentin did not exist. In addition, the ductal basal cells of normal salivary glands showed positive K8.12 labelling. The histogenesis of pleomorphic adenoma is discussed in relation to the differentiation of either ductal basal cells or ductal luminal cells from a single stem cell origin or the direct transformation of ductal basal cells to outer tumor cells and/or modified myoepithelial cells, both coexpressing K8.12 and vimentin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vimentina
/
Neoplasias das Glândulas Salivares
/
Adenoma Pleomorfo
/
Queratinas
Limite:
Humans
Idioma:
En
Revista:
J Oral Pathol Med
Ano de publicação:
1989
Tipo de documento:
Article