Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.

Shen, Rong; Liu, Hongliang; Wen, Juyi; Liu, Zhensheng; Wang, Li-E; Wang, Qiming; Tan, Dongfeng; Ajani, Jaffer A; Wei, Qingyi

Shen, Rong; Liu, Hongliang; Wen, Juyi; Liu, Zhensheng; Wang, Li-E; Wang, Qiming; Tan, Dongfeng; Ajani, Jaffer A; Wei, Qingyi.

Afiliação

Shen R; Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Liu H; Department of Chemotherapy, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Wen J; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
Liu Z; Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Wang LE; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
Wang Q; Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Tan D; Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Ajani JA; Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Wei Q; Department of GI Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Mol Carcinog ; 54(9): 880-8, 2015 Sep.

Article em En | MEDLINE | ID: mdl-24756984

Assuntos

MicroRNAs/metabolismo; Polimorfismo Genético; Neoplasias Gástricas/diagnóstico; Neoplasias Gástricas/genética; Estômago/patologia; Timidilato Sintase/genética; Idoso; Sítios de Ligação; Feminino; Mucosa Gástrica/metabolismo; Predisposição Genética para Doença; Genótipo; Haplótipos; Humanos; Masculino; Pessoa de Meia-Idade; Prognóstico; Fatores de Risco; Neoplasias Gástricas/epidemiologia; Neoplasias Gástricas/metabolismo; Análise de Sobrevida; Timidilato Sintase/química; Timidilato Sintase/metabolismo

Palavras-chave

gastric cancer; genetic susceptibility; microRNA; polymorphism; survival; thymidylate synthase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Estômago / Neoplasias Gástricas / Timidilato Sintase / MicroRNAs Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Carcinog Ano de publicação: 2015 Tipo de documento: Article

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