[Role of toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) in viral infections]. / Papel de los receptores tipo toll (TLRs) y receptores para dominios de oligomerización para la unión a nucleótidos (NLRs) en las infecciones virales.
Invest Clin
; 55(1): 61-81, 2014 Mar.
Article
em Es
| MEDLINE
| ID: mdl-24758103
ABSTRACT
The immune system (IS) cells are capable of recognizing a wide variety of microorganisms, through receptors that are expressed and distributed throughout the cell architecture. The interaction between the pathogen-associated molecular patterns or damage-associated molecular patterns (PAMPs or DAMPs) and pattern recognition receptors (PRR), present in host cells, is a critical event that involves intracellular signaling processes that end up in the expression of both, proinflammatory and antiviral mediators. Accordingly, the proper functioning of the different mechanisms of signal transduction from the cell membrane to the cytoplasm will depend on the integrity of these receptors (PRR); and therefore, the IS response triggered against pathogens including viral agents. Hence, in this review we discuss the role of toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) in viral infections, using as evidence the studies in humans and mice known to date.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
/
Receptores Toll-Like
/
Proteínas Adaptadoras de Sinalização CARD
/
Proteína Adaptadora de Sinalização NOD2
/
Interações Hospedeiro-Patógeno
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Es
Revista:
Invest Clin
Ano de publicação:
2014
Tipo de documento:
Article