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Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy.
Kwok, Hang Fai; Botkjaer, Kenneth A; Tape, Christopher J; Huang, Yanchao; McCafferty, John; Murphy, Gillian.
Afiliação
  • Kwok HF; Proteases and Tumour Microenvironment Group, Department of Oncology, Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China henry.kwok@cruk.cam.ac.uk gm290@cam.ac.uk.
  • Botkjaer KA; Proteases and Tumour Microenvironment Group, Department of Oncology, Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK Department of Molecular Biology and Genetics, University of Aarhus, Denmark.
  • Tape CJ; Proteases and Tumour Microenvironment Group, Department of Oncology, Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK Present address: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
  • Huang Y; Proteases and Tumour Microenvironment Group, Department of Oncology, Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
  • McCafferty J; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.
  • Murphy G; Proteases and Tumour Microenvironment Group, Department of Oncology, Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK henry.kwok@cruk.cam.ac.uk gm290@cam.ac.uk.
Protein Eng Des Sel ; 27(6): 179-90, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24769623
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas ADAM / Anticorpos de Cadeia Única / Antineoplásicos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Protein Eng Des Sel Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas ADAM / Anticorpos de Cadeia Única / Antineoplásicos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Protein Eng Des Sel Ano de publicação: 2014 Tipo de documento: Article