Wnt-responsive cancer stem cells are located close to distorted blood vessels and not in hypoxic regions in a p53-null mouse model of human breast cancer.

Vadakkan, Tegy J; Landua, John D; Bu, Wen; Wei, Wei; Li, Fuhai; Wong, Stephen T C; Dickinson, Mary E; Rosen, Jeffrey M; Lewis, Michael T; Zhang, Mei

Vadakkan, Tegy J; Landua, John D; Bu, Wen; Wei, Wei; Li, Fuhai; Wong, Stephen T C; Dickinson, Mary E; Rosen, Jeffrey M; Lewis, Michael T; Zhang, Mei.

Afiliação

Vadakkan TJ; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Landua JD; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Bu W; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Wei W; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Li F; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Wong ST; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Dickinson ME; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Rosen JM; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Lewis MT; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,
Zhang M; Department of Molecular Physiology and Biophysics, Lester & Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Systems Medicine and Bioengineering,

Stem Cells Transl Med ; 3(7): 857-66, 2014 Jul.

Article em En | MEDLINE | ID: mdl-24797826

Assuntos

Adenocarcinoma/irrigação sanguínea; Vasos Sanguíneos/patologia; Neoplasias Mamárias Experimentais/irrigação sanguínea; Neoplasias Mamárias Experimentais/metabolismo; Células-Tronco Neoplásicas/metabolismo; Neoplasias de Mama Triplo Negativas/irrigação sanguínea; Neoplasias de Mama Triplo Negativas/metabolismo; Proteína Supressora de Tumor p53/deficiência; Via de Sinalização Wnt; Adenocarcinoma/genética; Adenocarcinoma/patologia; Animais; Hipóxia Celular; Rastreamento de Células/métodos; Feminino; Genes Reporter; Vetores Genéticos; Proteínas de Fluorescência Verde/biossíntese; Proteínas de Fluorescência Verde/genética; Xenoenxertos; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Lentivirus/genética; Neoplasias Mamárias Experimentais/genética; Neoplasias Mamárias Experimentais/patologia; Camundongos; Microscopia Confocal; Microscopia de Fluorescência por Excitação Multifotônica; Transplante de Neoplasias; Células-Tronco Neoplásicas/patologia; Transdução Genética; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/patologia; Proteína Supressora de Tumor p53/genética; Via de Sinalização Wnt/genética

Palavras-chave

Cancer stem cells; In vivo optical imaging; Microvasculature; Signal transduction; Stem cell microenvironment; p53

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Vasos Sanguíneos / Adenocarcinoma / Proteína Supressora de Tumor p53 / Via de Sinalização Wnt / Neoplasias de Mama Triplo Negativas / Neoplasias Mamárias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Stem Cells Transl Med Ano de publicação: 2014 Tipo de documento: Article

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