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Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.
Lim, Maria A; Bence, Kendra K; Sandesara, Ishani; Andreux, Pénélope; Auwerx, Johan; Ishibashi, Jeff; Seale, Patrick; Kalb, Robert G.
Afiliação
  • Lim MA; Division of Neurology, Department of Pediatrics, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA, Neuroscience Graduate Group.
  • Bence KK; Neuroscience Graduate Group, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Sandesara I; Division of Neurology, Department of Pediatrics, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Andreux P; Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Auwerx J; Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Ishibashi J; Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Seale P; Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kalb RG; Division of Neurology, Department of Pediatrics, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA, Neuroscience Graduate Group, Department of Neurology and kalb@email.chop.edu.
Hum Mol Genet ; 23(18): 4995-5008, 2014 Sep 15.
Article em En | MEDLINE | ID: mdl-24833719
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Leptina / Esclerose Lateral Amiotrófica Limite: Animals / Humans / Male Idioma: En Revista: Hum Mol Genet Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Leptina / Esclerose Lateral Amiotrófica Limite: Animals / Humans / Male Idioma: En Revista: Hum Mol Genet Ano de publicação: 2014 Tipo de documento: Article