Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle.
Mar Drugs
; 12(5): 3060-71, 2014 May 22.
Article
em En
| MEDLINE
| ID: mdl-24857963
ABSTRACT
Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antozoários
/
Diterpenos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mar Drugs
Ano de publicação:
2014
Tipo de documento:
Article