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[UBE2B gene and male infertility: an update].
Zhonghua Nan Ke Xue ; 20(4): 367-71, 2014 Apr.
Article em Zh | MEDLINE | ID: mdl-24873167
ABSTRACT
Male infertility is a worldwide problem, and about 15% of the cases are associated with spermatogenesis-related gene mutation. The mammalian gene UBE2B is the homolog of the RAD6 gene of yeast, belonging to the ubiquitin proteasome system and playing an important role in spermatogenesis. Mice lacking the UBE2B gene are infertile, with reduced sperm motility, increased morphologically abnormal sperm, and inhibited meiosis of spermatogonia. Accumulated evidence shows that UBE2B gene mutants and single nucleotide polymorphisms are associated with male infertility. This article reviews the relation between the UBE2B gene and male infertility, offering some theoretical evidence for the diagnosis and treatment of male infertility.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espermatogênese / Polimorfismo de Nucleotídeo Único / Enzimas de Conjugação de Ubiquitina / Infertilidade Masculina / Mutação Limite: Animals / Humans / Male Idioma: Zh Revista: Zhonghua Nan Ke Xue Ano de publicação: 2014 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espermatogênese / Polimorfismo de Nucleotídeo Único / Enzimas de Conjugação de Ubiquitina / Infertilidade Masculina / Mutação Limite: Animals / Humans / Male Idioma: Zh Revista: Zhonghua Nan Ke Xue Ano de publicação: 2014 Tipo de documento: Article