Reduced prevalence of Giardia duodenalis in iron-deficient Rwandan children.
Trop Med Int Health
; 19(5): 563-7, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24898273
ABSTRACT
OBJECTIVE:
Acute symptomatic infection with Giardia duodenalis impairs iron absorption, but iron deficiency may protect against infections caused by various micro-organisms including parasites. We therefore examined the association of G. duodenalis infection and iron deficiency in 575 Rwandan children under 5 years of age.METHODS:
Giardia duodenalis infection was diagnosed by triplicate microscopy and PCR assays, and iron deficiency was defined as a ferritin concentration <12 ng/ml.RESULTS:
Largely asymptomatic G. duodenalis infection was seen in 65.3% of the children and iron deficiency in 17.4%. G. duodenalis infection was less common in iron-deficient children (51%) than in non-deficient children (68%, P = 0.002). In multivariate analysis, the odds of G. duodenalis infection were almost halved in iron-deficient children (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86).CONCLUSION:
In this highly endemic setting, there was no evidence that Giardia infection impairs iron status. Rather, iron deficiency appeared to protect against infection with this parasite.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Nutrição Infantil
/
Giardíase
/
Giardia lamblia
/
Deficiências de Ferro
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Child, preschool
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Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Trop Med Int Health
Ano de publicação:
2014
Tipo de documento:
Article