Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1-Bad-Bak pathway in peritoneal carcinomatosis.

Song, X; Dilly, A-K; Kim, S-Y; Choudry, H A; Lee, Y J

Song, X; Dilly, A-K; Kim, S-Y; Choudry, H A; Lee, Y J.

Afiliação

Song X; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Dilly AK; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kim SY; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Choudry HA; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Lee YJ; 1] Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA [2] Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, School of Medicine, Hillman Cancer Cen

Cell Death Dis ; 5: e1281, 2014 Jun 05.

Article em En | MEDLINE | ID: mdl-24901052

Assuntos

Adenocarcinoma/tratamento farmacológico; Antibióticos Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Mitomicina/farmacologia; Neoplasias Peritoneais/tratamento farmacológico; Proteínas Quinases S6 Ribossômicas 70-kDa/metabolismo; Sirolimo/farmacologia; Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo; Proteína de Morte Celular Associada a bcl/metabolismo; Adenocarcinoma/enzimologia; Adenocarcinoma/genética; Adenocarcinoma/patologia; Animais; Linhagem Celular Tumoral; Humanos; Camundongos; Camundongos Nus; Mitomicina/agonistas; Neoplasias Peritoneais/enzimologia; Neoplasias Peritoneais/genética; Neoplasias Peritoneais/patologia; Neoplasias Peritoneais/secundário; Proteínas Quinases S6 Ribossômicas 70-kDa/genética; Sirolimo/agonistas; Proteína Killer-Antagonista Homóloga a bcl-2/genética; Proteína de Morte Celular Associada a bcl/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Peritoneais / Adenocarcinoma / Mitomicina / Apoptose / Sirolimo / Proteínas Quinases S6 Ribossômicas 70-kDa / Proteína de Morte Celular Associada a bcl / Proteína Killer-Antagonista Homóloga a bcl-2 / Antibióticos Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2014 Tipo de documento: Article

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