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His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-ß-lactamase VIM-7.
Leiros, Hanna-Kirsti S; Skagseth, Susann; Edvardsen, Kine Susann Waade; Lorentzen, Marit Sjo; Bjerga, Gro Elin Kjæreng; Leiros, Ingar; Samuelsen, Ørjan.
Afiliação
  • Leiros HK; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway hanna-kirsti.leiros@uit.no.
  • Skagseth S; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
  • Edvardsen KS; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
  • Lorentzen MS; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
  • Bjerga GE; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
  • Leiros I; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
  • Samuelsen Ø; Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.
Antimicrob Agents Chemother ; 58(8): 4826-36, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24913158

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Fenilalanina / Pseudomonas aeruginosa / Beta-Lactamases / Proteínas Recombinantes de Fusão / Resistência beta-Lactâmica / Histidina / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Fenilalanina / Pseudomonas aeruginosa / Beta-Lactamases / Proteínas Recombinantes de Fusão / Resistência beta-Lactâmica / Histidina / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article