Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin.

Coburn, J; Dillon, S T; Iglewski, B H; Gill, D M

Coburn, J; Dillon, S T; Iglewski, B H; Gill, D M.

Afiliação

Coburn J; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts.

Infect Immun ; 57(3): 996-8, 1989 Mar.

Article em En | MEDLINE | ID: mdl-2492977

ABSTRACT

ABSTRACT

Exoenzyme S, which had been thought to be unselective, catalyzes the ADP-ribosylation of only a subset of cellular proteins. The intermediate filament protein vimentin is one of the more abundant substrates. Disassembled vimentin, and proteolytic fragments of vimentin that cannot form filaments, is more readily ADP-ribosylated than is filamentous vimentin.

Assuntos

ADP Ribose Transferases; Adenosina Difosfato Ribose/metabolismo; Toxinas Bacterianas; Citoesqueleto/metabolismo; Filamentos Intermediários/metabolismo; Poli(ADP-Ribose) Polimerases/metabolismo; Pseudomonas aeruginosa/enzimologia; Vimentina/metabolismo; Western Blotting; Eletroforese em Gel Bidimensional; Especificidade por Substrato

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Toxinas Bacterianas / Vimentina / Citoesqueleto / Filamentos Intermediários / Adenosina Difosfato Ribose / Poli(ADP-Ribose) Polimerases / ADP Ribose Transferases Idioma: En Revista: Infect Immun Ano de publicação: 1989 Tipo de documento: Article

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