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Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors.
Clemens, Jeremy J; Coon, Timothy; Busch, Brett B; Asgian, Juliana L; Hudson, Sarah; Termin, Andreas; Flores, Tina B; Tran, Dao; Chiang, Peggy; Sperry, Sam; Gross, Ray; Abt, Jeffrey; Heim, Roger; Lechner, Sandra; Twin, Heather; Studley, John; Brenchley, Guy; Collier, Philip N; Pierard, Francoise; Miller, Andrew; Mak, Chau; Dvornikovs, Vadims; Jimenez, Juan-Miguel; Stamos, Dean.
Afiliação
  • Clemens JJ; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States. Electronic address: jeremy_clemens@vrtx.com.
  • Coon T; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Busch BB; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Asgian JL; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Hudson S; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Termin A; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Flores TB; Department of Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Tran D; Department of Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Chiang P; Department of Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Sperry S; Department of Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Gross R; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Abt J; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Heim R; Department of Biology, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Lechner S; Department of Biology, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Twin H; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Studley J; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Brenchley G; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Collier PN; Department of Medicinal Chemistry, Vertex Pharmaceuticals, 50 Northern Avenue, Boston, MA 02210, United States.
  • Pierard F; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Miller A; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Mak C; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Dvornikovs V; Department of Medicinal Chemistry, Vertex Pharmaceuticals, 50 Northern Avenue, Boston, MA 02210, United States.
  • Jimenez JM; Department of Chemistry, Vertex Pharmaceuticals (Europe) Ltd, 86-88 Jubilee Avenue, Milton Park, Abingdon, Oxfordshire OX14 4RW, United Kingdom.
  • Stamos D; Department of Chemistry and Drug Innovation, Vertex Pharmaceuticals, 11010 Torreyana Road, San Diego, CA 92121, United States.
Bioorg Med Chem Lett ; 24(15): 3398-402, 2014 Aug 01.
Article em En | MEDLINE | ID: mdl-24939756
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucuronídeos / Inibidores de Proteínas Quinases / Proteína Quinase C-épsilon Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucuronídeos / Inibidores de Proteínas Quinases / Proteína Quinase C-épsilon Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article