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Sesquiterpenoids from Tussilago farfara and their inhibitory effects on nitric oxide production.
Qin, Zhi-Bin; Zhang, Jing; Wu, Xing-De; He, Juan; Ding, Lin-Fen; Peng, Li-Yan; Li, Xing-Yao; Li, Yan; Deng, Liang; Guo, Ya-Dong; Zhao, Qin-Shi.
Afiliação
  • Qin ZB; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • Zhang J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • Wu XD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • He J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • Ding LF; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People's Republic of China.
  • Peng LY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • Li XY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • Li Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
  • Deng L; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People's Republic of China.
  • Guo YD; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People's Republic of China.
  • Zhao QS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Planta Med ; 80(8-9): 703-9, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24963619
ABSTRACT
Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antitussígenos / Sesquiterpenos / Medicamentos de Ervas Chinesas / Lipopolissacarídeos / Tussilago / Óxido Nítrico Limite: Animals Idioma: En Revista: Planta Med Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antitussígenos / Sesquiterpenos / Medicamentos de Ervas Chinesas / Lipopolissacarídeos / Tussilago / Óxido Nítrico Limite: Animals Idioma: En Revista: Planta Med Ano de publicação: 2014 Tipo de documento: Article