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The effects of low-moderate dose prenatal ethanol exposure on the fetal and postnatal rat lung.
Probyn, M E; Cuffe, J S M; Zanini, S; Moritz, K M.
Afiliação
  • Probyn ME; School of Biomedical Sciences, Faculty of Science, The University of Queensland, St Lucia, Australia.
  • Cuffe JS; School of Biomedical Sciences, Faculty of Science, The University of Queensland, St Lucia, Australia.
  • Zanini S; School of Biomedical Sciences, Faculty of Science, The University of Queensland, St Lucia, Australia.
  • Moritz KM; School of Biomedical Sciences, Faculty of Science, The University of Queensland, St Lucia, Australia.
J Dev Orig Health Dis ; 4(5): 358-67, 2013 Oct.
Article em En | MEDLINE | ID: mdl-24970729
ABSTRACT
Little is known about whether exposure of the fetus to alcohol alters pulmonary development or function. This study aimed to determine whether low-moderate ethanol (EtOH) exposure throughout gestation alters structural and non-respiratory functional aspects of the fetal and postnatal lung. Sprague-Dawley rats were fed an ad libitum liquid diet ±6% v/v EtOH daily throughout pregnancy, achieving a plasma ethanol (EtOH) concentration of 0.03%. Gene and protein expression was determined in pulmonary tissue collected from fetuses at embryonic day (E) 20 and adult offspring. The percentage of airspace and alveolar size was measured in pulmonary tissue collected at postnatal day (PN) 1. At E20, EtOH-exposed fetuses had decreased aquaporin 5 mRNA levels and a non-significant trend for decreased epithelial sodium channel type α; expression of other pulmonary fluid homeostatic and development genes and surfactant protein genes were not different between groups. At PN1, there was no difference between EtOH-exposed and control offspring in the distal airspace percentage or diameter. At 8 months, collagen type III α1 gene expression was upregulated in EtOH-exposed male offspring; this was associated with increased collagen deposition at 10 months. At 19 months, male EtOH-exposed offspring had a 25% reduction in the protein levels of surfactant protein B. The alterations observed in male EtOH-exposed offspring suggest chronic low-moderate prenatal EtOH-exposure during development may result in increased pulmonary fibrosis. Such an alteration would decrease the respiratory capacity of the lung.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Dev Orig Health Dis Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Dev Orig Health Dis Ano de publicação: 2013 Tipo de documento: Article