Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0).
Beilstein J Org Chem
; 10: 1333-8, 2014.
Article
em En
| MEDLINE
| ID: mdl-24991286
ABSTRACT
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2014
Tipo de documento:
Article