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Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Li, Tianxia; Yang, Dejun; Zhong, Shijun; Thomas, Joseph M; Xue, Fengtian; Liu, Jingnan; Kong, Lingbo; Voulalas, Pamela; Hassan, Hazem E; Park, Jae-Sung; MacKerell, Alexander D; Smith, Wanli W.
Afiliação
  • Li T; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Yang D; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Zhong S; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Thomas JM; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Xue F; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Liu J; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Kong L; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Voulalas P; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Hassan HE; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Park JS; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • MacKerell AD; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
  • Smith WW; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA wsmith@rx.umaryland.edu.
Hum Mol Genet ; 23(23): 6212-22, 2014 Dec 01.
Article em En | MEDLINE | ID: mdl-24993787
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Sulfonas / Tiazóis / Proteínas Serina-Treonina Quinases / Guanosina Trifosfato / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Sulfonas / Tiazóis / Proteínas Serina-Treonina Quinases / Guanosina Trifosfato / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Ano de publicação: 2014 Tipo de documento: Article