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Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.
Czifrák, Katalin; Páhi, András; Deák, Szabina; Kiss-Szikszai, Attila; Kövér, Katalin E; Docsa, Tibor; Gergely, Pál; Alexacou, Kyra-Melinda; Papakonstantinou, Maria; Leonidas, Demetres D; Zographos, Spyros E; Chrysina, Evangelia D; Somsák, László.
Afiliação
  • Czifrák K; Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary.
  • Páhi A; Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary.
  • Deák S; Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary.
  • Kiss-Szikszai A; Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary.
  • Kövér KE; Department of Inorganic and Analytical Chemistry, University of Debrecen, POB 21, H-4010 Debrecen, Hungary.
  • Docsa T; Department of Medical Chemistry, Medical and Health Science Centre, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
  • Gergely P; Department of Medical Chemistry, Medical and Health Science Centre, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
  • Alexacou KM; Institute of Biology, Medicinal Chemistry and Biotechnology, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, GR-116 35 Athens, Greece.
  • Papakonstantinou M; Institute of Biology, Medicinal Chemistry and Biotechnology, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, GR-116 35 Athens, Greece.
  • Leonidas DD; Institute of Biology, Medicinal Chemistry and Biotechnology, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, GR-116 35 Athens, Greece.
  • Zographos SE; Institute of Biology, Medicinal Chemistry and Biotechnology, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, GR-116 35 Athens, Greece.
  • Chrysina ED; Institute of Biology, Medicinal Chemistry and Biotechnology, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, GR-116 35 Athens, Greece. Electronic address: echrysina@eie.gr.
  • Somsák L; Department of Organic Chemistry, University of Debrecen, POB 20, H-4010 Debrecen, Hungary. Electronic address: somsak@tigris.unideb.hu.
Bioorg Med Chem ; 22(15): 4028-41, 2014 Aug 01.
Article em En | MEDLINE | ID: mdl-25009003
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Glicogênio Fosforilase Muscular / Inibidores Enzimáticos / Tiazolidinas / Monossacarídeos Limite: Animals Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Glicogênio Fosforilase Muscular / Inibidores Enzimáticos / Tiazolidinas / Monossacarídeos Limite: Animals Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2014 Tipo de documento: Article