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Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.
Berger, Carola; Romero-Brey, Inés; Radujkovic, Danijela; Terreux, Raphael; Zayas, Margarita; Paul, David; Harak, Christian; Hoppe, Simone; Gao, Min; Penin, Francois; Lohmann, Volker; Bartenschlager, Ralf.
Afiliação
  • Berger C; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Romero-Brey I; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Radujkovic D; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Terreux R; CNRS, UMR5086, Bases Moléculaires et Structurales des Systèmes Infectieux, Institut de Biologie et Chimie des Protéines, Lyon, France; Labex Ecofect (ANR-11-LABX-0042), University of Lyon, Lyon, France; Faculté de Pharmacie (ISPB), Lyon, France.
  • Zayas M; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Paul D; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Harak C; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Hoppe S; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Gao M; Bristol-Myers Squibb Research and Development, Wallingford, Connecticut.
  • Penin F; CNRS, UMR5086, Bases Moléculaires et Structurales des Systèmes Infectieux, Institut de Biologie et Chimie des Protéines, Lyon, France; Labex Ecofect (ANR-11-LABX-0042), University of Lyon, Lyon, France.
  • Lohmann V; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Bartenschlager R; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany; German Centre for Infection Research, Heidelberg University, Heidelberg, Germany. Electronic address: Ralf_Bartenschlager@med.uni-heidelberg.de.
Gastroenterology ; 147(5): 1094-105.e25, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25046163
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Replicação Viral / Membrana Celular / Proteínas não Estruturais Virais / Hepacivirus / Hepatócitos / Imidazóis Tipo de estudo: Prognostic_studies Idioma: En Revista: Gastroenterology Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Replicação Viral / Membrana Celular / Proteínas não Estruturais Virais / Hepacivirus / Hepatócitos / Imidazóis Tipo de estudo: Prognostic_studies Idioma: En Revista: Gastroenterology Ano de publicação: 2014 Tipo de documento: Article