PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells.

Knoch, Klaus-Peter; Nath-Sain, Suchita; Petzold, Antje; Schneider, Hendryk; Beck, Mike; Wegbrod, Carolin; Sönmez, Anke; Münster, Carla; Friedrich, Anne; Roivainen, Merja; Solimena, Michele

Knoch, Klaus-Peter; Nath-Sain, Suchita; Petzold, Antje; Schneider, Hendryk; Beck, Mike; Wegbrod, Carolin; Sönmez, Anke; Münster, Carla; Friedrich, Anne; Roivainen, Merja; Solimena, Michele.

Afiliação

Knoch KP; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Nath-Sain S; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Petzold A; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Schneider H; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Beck M; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Wegbrod C; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Sönmez A; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Münster C; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Friedrich A; Paul Langerhans Institute Dresden, TU Dresden Germany ; German Center for Diabetes Research, 01307 Dresden, Germany.
Roivainen M; National Institute for Health and Welfare, Helsinki, Finland.
Solimena M; Paul Langerhans Institute Dresden, TU Dresden Germany ; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Mol Metab ; 3(5): 518-30, 2014 Aug.

Article em En | MEDLINE | ID: mdl-25061557

Palavras-chave

Beta cells; CV, Coxsackievirus; Diabetes; ER, endoplasmic reticulum; EV, Enterovirus; F, Faulkner; FL, firefly luciferase; IRES, internal ribosomal entry site; ITAF, IRES-trans-acting factor; Insulin; MCA, MIN6 cell adapted; PABP, poly(A)-binding protein; PC, prohormone convertase; PTBP1, polypyrimidine tract-binding protein 1; Polypyrimidine tract-binding protein; S6K1, p70S6 Kinase 1; Secretory granules; T1D, type 1 diabetes; Translation; UTR, untranslated region; Virus; eIF4E-V5, eIF4E tagged at its C-terminus with a V5-epitope; mTORC1, mammalian Target Of Rapamycin Complex 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Metab Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Metab Ano de publicação: 2014 Tipo de documento: Article