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Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells.
Jang, Soon Young; Kim, Aeree; Kim, Jin Kyoung; Kim, Chungyel; Cho, Youl-Hee; Kim, Jong-Ho; Kim, Chul Hwan; Lee, Ji-Yun.
Afiliação
  • Jang SY; Department of Pathology, College of Medicine, Korea University, Seoul, South Korea.
  • Kim A; Department of Pathology, College of Medicine, Korea University, Seoul, South Korea Department of Pathology, Korea University Guro Hospital, Seoul, South Korea.
  • Kim JK; Department of Pathology, College of Medicine, Korea University, Seoul, South Korea Department of Pathology, Korea University Guro Hospital, Seoul, South Korea.
  • Kim C; Department of Pathology, College of Medicine, Korea University, Seoul, South Korea Department of Pathology, Korea University Guro Hospital, Seoul, South Korea.
  • Cho YH; Department of Medical Genetics, College of Medicine, Hanyang University, Seoul, South Korea.
  • Kim JH; Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, South Korea.
  • Kim CH; Department of Pathology, College of Medicine, Korea University, Seoul, South Korea jiyun-lee@korea.ac.kr chkap@korea.ac.kr.
  • Lee JY; Department of Pathology, College of Medicine, Korea University, Seoul, South Korea jiyun-lee@korea.ac.kr chkap@korea.ac.kr.
Anticancer Res ; 34(8): 4127-34, 2014 Aug.
Article em En | MEDLINE | ID: mdl-25075039
Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamoxifeno / Neoplasias da Mama / Movimento Celular / Metaloproteinase 9 da Matriz / Metformina Limite: Female / Humans Idioma: En Revista: Anticancer Res Ano de publicação: 2014 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamoxifeno / Neoplasias da Mama / Movimento Celular / Metaloproteinase 9 da Matriz / Metformina Limite: Female / Humans Idioma: En Revista: Anticancer Res Ano de publicação: 2014 Tipo de documento: Article