Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.

Li, Zhenyu; Jia, Lejiao; Wang, Jifeng; Wu, Xingkang; Hao, Huilin; Xu, Hongjiao; Wu, Yunfei; Shi, Guowei; Lu, Chunhua; Shen, Yuemao

Li, Zhenyu; Jia, Lejiao; Wang, Jifeng; Wu, Xingkang; Hao, Huilin; Xu, Hongjiao; Wu, Yunfei; Shi, Guowei; Lu, Chunhua; Shen, Yuemao.

Afiliação

Li Z; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Jia L; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Wang J; Department of Urology, The Fifth People's Hospital of Shanghai, Fudan University, No. 801 Heqing Road, Shanghai 200240, PR China; Urology Research Center, Fudan University, No. 801 Heqing Road, Shanghai 200240, PR China.
Wu X; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Hao H; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Xu H; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Wu Y; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Shi G; Department of Urology, The Fifth People's Hospital of Shanghai, Fudan University, No. 801 Heqing Road, Shanghai 200240, PR China; Urology Research Center, Fudan University, No. 801 Heqing Road, Shanghai 200240, PR China.
Lu C; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Shen Y; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China. Electronic address: yshen@sdu.edu.cn.

Eur J Med Chem ; 85: 359-70, 2014 Oct 06.

Article em En | MEDLINE | ID: mdl-25105924

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Benzoquinonas/síntese química; Benzoquinonas/farmacologia; Desenho de Fármacos; Proteínas de Choque Térmico HSP90/antagonistas & inibidores; Lactamas Macrocíclicas/síntese química; Lactamas Macrocíclicas/farmacologia; Animais; Antineoplásicos/química; Antineoplásicos/toxicidade; Benzoquinonas/química; Benzoquinonas/toxicidade; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Técnicas de Química Sintética; Proteínas de Choque Térmico HSP90/química; Humanos; Lactamas Macrocíclicas/química; Lactamas Macrocíclicas/toxicidade; Fígado/efeitos dos fármacos; Masculino; Camundongos; Modelos Moleculares; Conformação Proteica

Palavras-chave

Antitumor activities; Geldanamycin; Hepatotoxicity; Hsp90; Molecular dynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Benzoquinonas / Proteínas de Choque Térmico HSP90 / Lactamas Macrocíclicas / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Ano de publicação: 2014 Tipo de documento: Article

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